Renoprotective effects of human L-type fatty acid-binding protein (hL-FABP) in rhabdomyolysis-induced acute kidney injury.

ABSTRACT: L-type fatty acid-binding protein (L-FABP) in proximal tubules is reported to reduce oxidative stress. This study investigated whether renal L-FABP mitigated rhabdomyolysis (RM)-induced acute kidney injury (AKI). Wild-type (WT) mice, which lack renal L-FABP expression, and human L-FABP (hL-FABP) chromosomal transgenic (Tg) mice, which express hL-FABP in proximal tubules, were divided into RM (WT-RM, Tg-RM) and control (WT-Cont, Tg-Cont) groups. RM was induced via intramuscular injection of 50% glycerol/PBS into the quadriceps, whereas controls received PBS alone. On day 1, the WT-RM and Tg-RM groups exhibited similar increases in serum myoglobin, renal dysfunction, heme oxygenase-1 expression, and tubulointerstitial damage. By day 3, the Tg-RM group demonstrated significant improvements in

SUBMITTER: Inoue K 

PROVIDER: S-EPMC12855215 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature