Cerebral cavernous malformations in pregnancy: A systematic review of case reports and case series of hemorrhagic risk and outcomes.

ABSTRACT: Cavernous malformations (CMs) are vascular lesions that can lead to seizures or hemorrhage. Although pregnancy involves hormonal and circulatory changes that might influence CM behavior, whether it increases the risk of bleeding is unclear. We performed a systematic review using PubMed/MEDLINE and Scopus of published reports describing pregnant women diagnosed with cerebral or spinal CMs. The study question was framed using the PEO strategy, with pregnant women with cavernous angioma as the population, hemorrhage as the exposure, and clinical outcomes as the endpoints. The search was updated to July 12th, 2025 with no time restrictions. This review followed the PRISMA 2020 guidelines. Thirty-two studies were selected accounting for 94 patients. Most lesions were localized in the brainstem

SUBMITTER: Palermo M 

PROVIDER: S-EPMC12855374 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature