Genetic evidence of the causal relationship between genetically predicted nutrients and psoriatic arthritis.

ABSTRACT:

Background

Recently, the importance of nutrients in managing the immune system and inflammation has garnered increasing attention. Research indicates that different nutrients can either reduce or promote inflammation within the immune system. Considering that psoriatic arthritis is a chronic immune-mediated inflammatory disorder, this research sought to investigate potential causal relationships between genetically predicted levels of 25 nutrients and psoriatic arthritis, providing insights into disease pathogenesis and therapeutic strategies.

Patients and methods

This study performed a two-sample Mendelian randomization (MR) study along with subsequent meta-analysis. Exposures comprised 25 circulating nutrients, instrumented by genetic variants (IVs), low linkage disequilib

SUBMITTER: Zhao J 

PROVIDER: S-EPMC12855376 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature