Risk factors and predictive modeling for occult endometrial cancer in women with atypical hyperplasia: a retrospective study.

ABSTRACT:

Purpose

Atypical endometrial hyperplasia (AEH) is a known precursor to endometrioid endometrial carcinoma. However, occult carcinoma may already be present at diagnosis, complicating surgical planning. Accurate preoperative risk stratification is crucial, especially for guiding the selective use of sentinel lymph node biopsy. This study aimed to identify predictors of occult carcinoma and develop a model to estimate the risk of malignancy.

Methods

We conducted a retrospective case-control study of 101 women diagnosed with AEH who underwent hysterectomy between 2010 and 2024 at Galilee Medical Center. Clinical, metabolic, and imaging data were extracted. Patients were stratified based on the final pathology into two groups: those with occult carcinoma and those with AEH only.

SUBMITTER: Wolff K 

PROVIDER: S-EPMC12855440 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature