Comparative effectiveness of ertapenem versus other empirical antibiotics in elderly patients with complicated intra-abdominal infection: a real-world inverse probability of treatment weighting study.

ABSTRACT:

Background

Elderly adults with complicated intra-abdominal infection (cIAI) represent a functionally immunocompromised population due to immunosenescence, multimorbidity, and frailty. Optimizing empirical antibiotic therapy in this group is essential to improve outcomes while minimizing unnecessary broad-spectrum antimicrobial exposure and antimicrobial resistance (AMR) selection pressure. Ertapenem is a once-daily carbapenem with favorable pharmacological properties, yet contemporary real-world comparative data in older adults are limited.

Methods

We conducted a retrospective, real-world comparative-effectiveness study of hospitalized adults aged ≥65 years with cIAI at a tertiary academic medical center from 2019 to 2025. Eligible patients received empirical monotherapy wit

SUBMITTER: Sun Y 

PROVIDER: S-EPMC12855448 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature