Histone lactylation-derived TET2 enhanced Arg1-mediated MDSC immunosuppression.

ABSTRACT: In the tumor microenvironment (TME), tumor cells secrete a large amounts of lactate due to the "Warburg effect", which plays a significant role in regulating gene transcription. Recently, the role of lactate in gene transcription has been increasingly understood. Myeloid-derived suppressor cells (MDSCs) are inhibitory cells of bone marrow origin that possess marked abilities to suppress immune cell responses. Within the TME, MDSCs inhibit T cell-mediated specific anti-tumor immunity, as well as non-specific anti-tumor immunity mediated by NK cells and macrophages, by expressing high levels of Arg1, iNOS, and ROS.

Methods

This study used the Lewis lung carcinoma cell line to establish a lung cancer xenograft model; MDSCs were isolated from the spleens of these mice for subsequent exp

SUBMITTER: Da W 

PROVIDER: S-EPMC12855476 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature