HIV-1 drug resistance and genetic clustering among ART-treated individuals with virologic failure in Aksu, China.

ABSTRACT:

Background

Aksu Prefecture is among the regions most heavily affected by HIV-1 in China, yet data on acquired drug resistance (ADR) among antiretroviral therapy (ART)-treated individuals with virologic failure remain limited. This study aimed to characterize the prevalence, mutation patterns, and genetic clustering of drug resistance mutations (DRMs) in Aksu.

Methods

We conducted a retrospective study among ART-treated individuals with virologic failure in Aksu Prefecture from 2022 to 2023. HIV-1 pol sequences were obtained from 675 individuals to identify DRMs. Genetic networks were constructed to assess clustering among individuals harboring DRMs (n = 407). Univariable and multivariable logistic regression analyses were used to identify factors associated with DRMs

SUBMITTER: Dai Z 

PROVIDER: S-EPMC12855523 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature