HD-tDCS over prefrontal cortex alleviates the inhibitory control and sleep problems of insomnia with objective short sleep duration.

ABSTRACT:

Background

Insomnia disorder with objective short sleep duration (ISSD) is a severe phenotype associated with significant health risks including hypertension, diabetes, and cognitive impairment. It has been found that sleep problems in ISSD can be alleviated by improving inhibitory control (IC) ability. Therefore, there is a need to develop more effective interventions targeting inhibitory control to relief the symptom in ISSD.

Objective

This study aimed to investigate whether high-definition transcranial direct current stimulation (HD-tDCS) targeting the right dorsolateral prefrontal cortex (dlPFC) could improve inhibitory control and sleep quality in ISSD.

Methods

In a randomized, single-blind, sham-controlled trial, 50 ISSD were assigned to real (n = 25) or sham (n

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12855548 | biostudies-literature | 2026 Jan-Mar

REPOSITORIES: biostudies-literature