Immune signatures of sepsis from mild infection to critical illness - a prospective observational study.

ABSTRACT: Sepsis-induced immunosuppression is a phenomenon characterized by the development of several changes in immunophenotype which predispose to secondary infections and increased mortality risk. Immunomodulatory therapies have yet to reproducibly demonstrate benefit in large clinical trials. We propose that several changes consistent with an immunosuppressive phenotype in sepsis represent either adaptive changes or epiphenomenon, rather than direct drivers of outcome in infection and sepsis. We therefore conducted a prospective observational study of patients presenting with infections with a spectrum of illness severity, to evaluate canonical features of monocyte and lymphocyte immunosuppression using flow cytometry. Several features consistent with immunosuppression in sepsis are observed in

SUBMITTER: Snow TAC 

PROVIDER: S-EPMC12855556 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature