The mechanism of secreted frizzled-related protein 1 in alleviating cardiomyocyte injury and heart failure.

ABSTRACT: Heart failure (HF) is a clinical syndrome characterized by impairment of the heart's pumping function. Its core pathological basis is the vicious cycle of "injury reconstruction decompensation" triggered by cardiomyocyte damage. This review aims to systematically elucidate the molecular mechanism by which secreted frizzled-related protein 1 (Sfrp1; all proteins mentioned in the article are mouse genes, and Sfrp1 is used as the abbreviation) alleviates myocardial injury and delays the progression of HF through a multi-pathway interaction network. The main contents include (1) the core pathological mechanism of HF, such as oxidative stress (excessive ROS leads to calcium overload and mitochondrial apoptosis), autophagy disorder (the AngII/β5i axis inhibits protective autophagy), and abnormal

SUBMITTER: He Y 

PROVIDER: S-EPMC12855572 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature