Nephrotoxicity and kidney outcomes in pediatric oncology patients.

ABSTRACT:

Background

Acute kidney injury (AKI) is a serious complication during pediatric cancer treatment. Nephrotoxic medication may increase the risk of developing AKI, which may necessitate modifications to standard treatment and may also increase the risk of chronic kidney disease (CKD). This study investigates the incidence of AKI, the impact of nephrotoxic medications and the association between AKI and the development of CKD.

Methods

In this retrospective national cohort study, we analyzed 1525 pediatric cancer patients treated at the Princess Máxima Center between 2015 and 2021. AKI was classified using KDIGO criteria based on serum creatinine. The effect of nephrotoxic medications and other risk factors on AKI incidence and progression was assessed by using a cause specific

SUBMITTER: Raymakers-Janssen PAMA 

PROVIDER: S-EPMC12855606 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature