Hepatitis A to E in People with HIV: A Virus-Specific Review of Prevention and Treatment.

ABSTRACT: People with HIV (PWH) are disproportionately affected by viral hepatitis as a result of overlapping transmission routes, reduced vaccine immunogenicity, altered disease progression, and unique therapeutic considerations under HIV-related immunosuppression. Although the scale-up of antiretroviral therapy (ART) and direct-acting antivirals (DAAs) has significantly improved outcomes, viral hepatitis remains a major cause of liver-related morbidity and mortality in this population. This virus-specific review summarizes current knowledge and recent advances in the epidemiology, vaccination, and treatment strategies for hepatitis A through E (i.e., hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), and hepatitis E virus (HEV); HAV-HEV) among PWH.

SUBMITTER: Lin KY 

PROVIDER: S-EPMC12855662 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature