Long-Term Antibody Persistence After Hepatitis A Vaccination in Healthy Toddlers: Insights from Modeling.

ABSTRACT:

Introduction

Argentina was the first South American country to adopt a single-dose hepatitis A vaccine for 1-year-old children, replacing the standard two-dose regimen in the immunization program in 2005. Here, we assessed the long-term persistence of anti-hepatitis A virus (HAV) antibodies following vaccination.

Methods

A cohort of healthy toddlers from Mendoza, Argentina, who received one (N = 436) or two (N = 108) doses of the inactivated HAV vaccine (Avaxim^® 80U Pediatric), were followed for up to 15 years post-vaccination to assess the persistence of anti-HAV antibodies. Three assays were used to measure anti-HAV antibody concentrations, depending on commercial availability. At year 15 follow-up, 161 and 48 participants who received one and two vaccine doses,

SUBMITTER: Espul C 

PROVIDER: S-EPMC12855680 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature