Generative artificial intelligence in palliative care: A comparative evaluation of ChatGPT-4o and ChatGPT-5 as clinical decision support tools.

ABSTRACT:

Background and objective

Generative artificial intelligence (AI) tools such as ChatGPT are increasingly integrated into healthcare, with potential to support clinical decision-making and improve patient outcomes. In palliative care, where access to multidisciplinary expertise is often limited, these tools may provide support for symptom management. This study aimed to systematically compare ChatGPT-4o and ChatGPT-5 for common palliative care symptoms across four key domains: clinical appropriateness, safety, ethical sensitivity, and understandability.

Methods

Clinical scenarios representing 10 key symptoms (pain, anxiety, pressure ulcer, nausea, delirium, dyspnea, constipation, diarrhea, dry mouth, and sleep disturbance) were presented first to ChatGPT-4o and, 1 week later,

SUBMITTER: Vuraloglu E 

PROVIDER: S-EPMC12855733 | biostudies-literature | 2026 Jan-Dec

REPOSITORIES: biostudies-literature