Comparing the pharmacokinetics of GS-441524 after intravenous and oral administration of remdesivir in New Zealand cats with feline infectious peritonitis.

ABSTRACT: ObjectivesThe aim of the study was to compare the pharmacokinetics of GS-441524 after intravenous (IV) and oral administration of compounded remdesivir (RDV) at 30 mg/kg, respectively, in cats with clinical feline infectious peritonitis (FIP) and to determine the bioavailability of GS-441524 after oral administration of compounded RDV in this population.MethodsA total of 13 client-owned cats with a clinical diagnosis of FIP were prospectively recruited. To reflect real-world use, RDV (30 mg/kg) was administered via a 20-min IV infusion or orally (rounded up to capsule size). Plasma GS-441524 concentrations were measured at eight time points over 24 h after administration. Pharmacokinetic parameters were determined by non-compartment analysis followed by bioavailability calculation.ResultsP

SUBMITTER: Renner KA 

PROVIDER: S-EPMC12855771 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature