Analysis of DNA methyltransferase 3 alpha expression during respiratory syncytial virus strain A infection.

ABSTRACT: Respiratory syncytial virus (RSV) is a seasonal pathogen known to cause lower respiratory tract infections, including bronchiolitis and pneumonia, and it is associated with an increased risk of developing asthma and recurrent wheezing in pediatric populations. Epigenetic mechanisms, such as DNA methylation and histone modifications, have been implicated in regulating host immune responses during viral infections. In this study, we investigated DNMT3A expression, a de novo DNA methyltransferase, during RSV infection. We queried the Gene Expression Omnibus (GEO) database for RNA-sequencing datasets related to RSV infection. Among the five relevant datasets identified, one demonstrated significantly elevated DNMT3A expression in RSV-infected samples compared to controls. To validate and furth

SUBMITTER: Becker AL 

PROVIDER: S-EPMC12855837 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature