Immunoinformatics-based design and evaluation of a multi-epitope vaccine against Vibrio fluvialis.

ABSTRACT: Vibrio fluvialis is an emerging foodborne pathogen causing gastroenteritis and extraintestinal infections, representing a significant public health concern due to rising antimicrobial resistance and the absence of an approved vaccine. This study aimed to design a multi-epitope subunit vaccine against V. fluvialis using immunoinformatics and a standard multi-epitope vaccine design pipeline. Two surface-exposed immunogenic membrane proteins, ATP-dependent zinc metalloprotease FtsH and lytic murein transglycosylase F, were selected as antigenic targets. Ten epitopes, including four MHC class I, four MHC class II, and two B-cell epitopes, were predicted and assembled into a 246 amino acid vaccine construct. The construct showed an antigenicity score of 0.8610. Population coverage analysis indi

SUBMITTER: Naveed M 

PROVIDER: S-EPMC12855877 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature