Dynamics of brain connectivity across the Alzheimer's disease spectrum through magnetoencephalography.

ABSTRACT: Changes in static functional connectivity have been extensively linked to Alzheimer's Disease (AD), however, dynamic functional connectivity (dFC) across the AD continuum remains understudied. The current investigation leverages the high temporal resolution of MEG to dissect the dynamics of brain connectivity alterations across various stages of AD and their association with cognitive decline and structural brain changes. 321 participants were included, categorized into healthy control, subjective cognitive decline (SCD), and mild cognitive impairment (MCI) groups. Amplitude envelope correlation with leakage correction was calculated over MEG signals using a sliding window, and the correlation across epochs was studied to assess dFC. We explored dFC associations with cognitive scores, grey

SUBMITTER: Carrasco-Gomez M 

PROVIDER: S-EPMC12855899 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature