Age- and sex-dependent bone marrow adiposity and distinct transcriptional trajectories in endothelial subtypes.

ABSTRACT: The bone marrow vascular niche is a highly specialized network essential for governing the maintenance, differentiation, and mobilization of tissue-resident stem cells, notably hematopoietic stem cells. With ageing, the spatial organization and functional integrity of this vasculature undergo significant decline. While prior studies have characterized broad vessel types into arterioles, sinusoids, and transitional capillaries, the molecular heterogeneity and spatial structural remodeling of the bone marrow endothelium during ageing remain poorly defined. Through a multi-modal analysis of murine tibial bone marrow across the lifespan, we demonstrate that vascular remodeling is a spatially heterogeneous process characterized by profound sex-specific differences. Structurally, ageing precipit

SUBMITTER: Syed UI 

PROVIDER: S-EPMC12855906 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature