Ventral subicular pyramidal neurons contribute to epileptogenesis via anterior thalamic circuit.

ABSTRACT: The subiculum contains functionally distinct dorsal and ventral subdivisions and is implicated in temporal lobe epilepsy (TLE). Yet, the contribution of ventral subicular glutamatergic neurons (vSub^glu) to epileptogenesis remains unclear. Using in vivo fiber photometry and c-Fos mapping in a hippocampal-kindling TLE model, we identified pronounced hyperactivation of vSub^glu during seizure development. Optogenetic activation of vSub^glu alone recapitulated the kindling process and accelerated kindling progression when applied following electrical stimulation. Conversely, optogenetic or chemogenetic inhibition of vSub^glu robustly suppressed seizure development in both the kindling model and the acute KA model and delayed epileptogenesis in the chron

SUBMITTER: Gong Y 

PROVIDER: S-EPMC12855924 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature