Defining the marker and developmental trajectory of myeloid-derived suppressor cells in aging by single-cell transcriptomics.

ABSTRACT: Myeloid-derived suppressor cells (MDSCs) are recognized as a key mediator of immunosuppression in aging, which induce immunosenescence and increase elderly people's susceptibility to infections, cancers, autoimmune diseases, and degenerative diseases. However, the commonly used MDSC markers overlap with those defining healthy and normal neutrophils or monocytes, which makes it challenging to distinguish MDSCs from their myeloid counterparts, and hampers deeper understanding of the pathophysiological functions of MDSCs. In this study, we compared MDSCs from aged mice to young controls using single-cell RNA sequencing. We established MDSC-specific gene signature, which revealed the general characteristics of MDSCs during aging, and thus facilitating distinguishing them from normal myeloid ce

SUBMITTER: Su Y 

PROVIDER: S-EPMC12855942 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature