The dynamics of mutational selection in cutaneous squamous carcinogenesis.

ABSTRACT: Identifying the mutant genes that are selected during carcinogenesis is key to identifying candidates for intervention and understanding the processes that promote transformation. Here we applied two selection metrics to study the dynamics of mutational selection in a mouse model of ultraviolet light driven skin carcinogenesis in which multiple synchronous tumors develop in each animal. Sequencing normal skin and tumors over a time course revealed two genetic routes to squamous carcinoma. Nonsynonymous Trp53 mutants were positively selected in both epidermis and tumors and present in 90% of tumors. The remaining tumors carried other oncogenic mutants, including activating Kras mutations. However, other positively selected mutant genes lost their competitive advantage in heavily mutated epi

SUBMITTER: Skrupskelyte G 

PROVIDER: S-EPMC12855962 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature