Microwave synthesis of new naproxen analogues for chronic inflammation and their gastro-protective effect in post-operative model.

ABSTRACT: In the present study, novel naproxen analogues (NS9-NS12) were synthesized under microwave irradiation and characterized by ¹H NMR, ¹³C NMR, and HR-ESI-MS advanced spectroscopic techniques. Their analgesic, anti-inflammatory and gastro-protective activities were evaluated in postoperative and chronic inflammatory pain models. Analgesic activity was determined by Eddy Hot plate and Acetic-induced Writhing tests using dose of 30 mg/kg (b.wt), while anti-inflammatory activity was determined by Egg induced method. Additionally, dose 1, 3, 10 and 30 mg/kg (b.wt) were used for post-operative pain and ulcerogenicity was assessed at 100 and 150 mg/kg(b.wt) after finding that all naproxen analogues were safe. Among all analogues, NS12 showed high significant (p < 0.001 increas

SUBMITTER: Shah NZ 

PROVIDER: S-EPMC12855984 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature