The rise and spread of invasive emm49 Streptococcus pyogenes in the USA.

ABSTRACT: Background. The propensity of Streptococcus pyogenes (group A Streptococcus) to invade normally sterile sites and cause invasive group A Streptococcus (iGAS) disease varies across strains, which are classified using the emm gene. Between 2015 and 2017, multistate iGAS surveillance identified an ~150-fold increase of one particular emm type, emm49. This genomic epidemiological analysis aimed to identify bacterial, patient and societal factors associated with this expansion.Methods. We analysed 1322 emm49 iGAS cases and the genome sequences of the clinical isolates acquired through the population-based Active Bacterial Core surveillance during 2015-2022. For each invasive case, we received both a cultured isolate and a standardiz

SUBMITTER: Metcalf B 

PROVIDER: S-EPMC12856021 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature