Early radiobiological effects of flattening filter (FF) and flattening filter-free (FFF) beams and the radioprotective role of melatonin in rat brain: a preclinical study.

ABSTRACT: The study aimed to investigate early radiobiological effects of Flattening Filter (FF) and Fattening Filter-Free (FFF) beams on brain tissue in experimental rat models and to evaluate the potential radioprotective role of melatonin (MEL) using histopathological and biochemical parameters. Forty female Wistar albino rats were randomly assigned to five groups: control (G1), FF (G2), FF + MEL (G3), FFF (G4) and FFF + MEL (G5). A single 16 Gy dose was delivered to the head and neck region in G2 and G4. MEL (50 mg/kg) was administered intraperitoneally 15 minutes before irradiation in G3 and G5. Forty-eight hours post-irradiation, serum samples were analyzed for M30, M65, TAS, TOS and OSI. Brain and cerebellar tissues were histologically examined for neuronal degeneration, vascular dilatation,

SUBMITTER: Baz Cifci SB 

PROVIDER: S-EPMC12856033 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature