Prediabetes Associates With Musculoskeletal Alterations Independent of Total Body Adiposity.

ABSTRACT:

Background

Excess adiposity is a major risk factor for insulin resistance, prediabetes, and Type 2 diabetes and increases the risk for sarcopenia and osteosarcopenia later in life. It has been proposed that altered metabolic function and musculoskeletal status in people with obesity are directly linked, presumably because they share common pathophysiological mechanisms. However, the effect of metabolic dysfunction, independent of adiposity, on musculoskeletal status is unknown.

Methods

We performed a comprehensive assessment of musculoskeletal status in people with overweight/obesity and prediabetes (n = 12; 72% women; age: 67 ± 6 years; weight: 81 ± 11 kg; mean ± SD) and a control group of sex-, age- and adiposity-matched participants with normoglycaemia (n = 18; 67% women;

SUBMITTER: Fappi A 

PROVIDER: S-EPMC12856049 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature