Substitutions of Sleep, Physical Activity, and Sedentary Behaviour and the Risk of Dementia and Stroke.

ABSTRACT: Sleep, sedentary behaviour, and physical activity (PA) are important for brain health. Spending more time in one behaviour always substitutes time in another, which may affect associations and should be considered in prevention strategies. We assessed how substitutions of sleep, sedentary behaviour, and PA are associated with incident dementia and stroke, using compositional analysis. Participants (mean age: 71.3 ± 9.26 years, 51.6% female) without prevalent dementia (N = 1899) or stroke (N = 1854) from the Rotterdam Study wore an accelerometer for ≥ 4 days to estimate the duration of sleep, sedentary behaviour, light PA, and moderate-to-vigorous PA. Participants were continuously followed up for dementia (median: 4.5 years) and stroke (median: 5.1 years). Compositional Cox regression with

SUBMITTER: Hoepel SJW 

PROVIDER: S-EPMC12856126 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature