Does It Matter What Keeps You Awake? Effects of Two Different Sleep Deprivation Methods on Object-Location Memory and Hippocampal c-Fos Expression in Mice.

ABSTRACT: In sleep research, various sleep deprivation methods have been used to examine the effects of sleep loss on memory. However, studies often overlook the distinct impacts each method may have on activity in specific neuronal circuits and memory storage. It remains unclear whether these changes following sleep deprivation result from extended wakefulness alone or from an interaction with the nature of the waking experience. To address this question, we examined how two commonly used sleep deprivation methods in mice-gentle handling and novelty-induced sleep deprivation-affect object-location memory and hippocampal c-Fos expression. Using either method, mice were sleep deprived for 3 or 6 h immediately after training in the object-location memory task, and spatial memory performance was assess

SUBMITTER: Sarma A 

PROVIDER: S-EPMC12856129 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature