Prevention of Postoperative Delirium in Patients Undergoing Elective Surgery Using Multicomponent Interventions: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

ABSTRACT:

Background and hypothesis

Postoperative delirium (POD) is a common acute cognitive disorder among older adults following elective surgery. It prolongs hospitalization, increases the risk of complications and readmission, and may contribute to long-term cognitive decline, thereby reducing patients' quality of life. Although various preventive strategies have been developed, single interventions often yield limited efficacy. This study systematically evaluates, through meta-analysis, the effectiveness of multicomponent interventions in preventing POD among older adults undergoing elective surgery.

Study design

A systematic search was conducted in PubMed, Embase, Web of Science, and the Cochrane Library for randomized controlled trials (RCTs) published through July 2025. Risk r

SUBMITTER: Yang X 

PROVIDER: S-EPMC12856225 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature