A swine model of severe chronic thromboembolic pulmonary hypertension induced by repeated pulmonary artery long suture injection.

ABSTRACT:

Introduction

Large animal models are key to translational research. Current models of chronic thromboembolic pulmonary hypertension (CTEPH) are rather complex, impractical and most fail to achieve a severe PH and right ventricular (RV) dysfunction phenotype. Our aim was to develop a plain large animal model of severe CTEPH with RV dysfunction.

Methods

In 3 consecutive weeks, 2-month-old male pigs (∼25 kg) randomly underwent either left and right pulmonary artery (PA) injection of 15-30 15 cm #0 silk sutures (CTEPH, n = 9) or sham procedure (Sham, n = 6). Embolization was interrupted based on mean PA pressure (mPAP) elevation, cardiac output (CO) or systemic blood pressure decline, or complete obstruction on angiography. After 4 weeks of follow-up, we assessed e

SUBMITTER: Moreira-Costa L 

PROVIDER: S-EPMC12856298 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature