Amyloid-related default mode network hyperconnectivity and longitudinal decline in network distinctiveness in preclinical Alzheimer's disease.

ABSTRACT:

Introduction

We investigated stage-specific alterations in functional connectivity (FC) of the default mode network (DMN) across the Alzheimer's disease (AD) continuum and tested whether early amyloid beta (Aβ)-related changes in within-DMN FC (DMN-FC_within) predicted longitudinal alterations in DMN between-network connectivity (DMN-FC_between).

Methods

Resting-state functional magnetic resonance imaging (fMRI) data were analyzed from 396 older adults: Aβ-negative cognitively normal (CN-, n = 213), Aβ-positive CN (CN+, n = 37), Aβ-positive mild cognitive impairment (MCI+, n = 72), and Aβ-positive dementia (dementia+, n = 74). Cross-sectional analyses compared DMN-FC across groups and examined associations with continuous Aβ burden at baseline. Longitudin

SUBMITTER: Cha WJ 

PROVIDER: S-EPMC12856376 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature