Choroid plexus alterations in long COVID and their associations with Alzheimer's disease risks.

ABSTRACT:

Introduction

Choroid plexus (ChP) enlargement is a neuroimaging biomarker of neuroinflammation and neurodegeneration. However, evidence of ChP structural and perfusion alterations in long coronavirus disease (COVID) and their clinical relevance remains limited.

Methods

This study included 86 long COVID, 67 recovered COVID, and 26 COVID-negative healthy controls (HCs). ChP volume and cerebral blood flow (CBF) were quantified, and their associations with Alzheimer's disease (AD) symptoms and plasma biomarkers were examined.

Results

Both patient groups showed higher ChP volume and lower CBF than HC. Relative to recovered COVID, long COVID patients had a larger ChP volume, but no significant difference in CBF. ChP volume correlated positively with glial fibrillary acidic

SUBMITTER: Pang H 

PROVIDER: S-EPMC12856380 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature