Decoding Causal Associations Between Neuropsychiatric Disorders and Rotator Cuff Tendinopathy: A Two-Sample Mendelian Randomization Study.

ABSTRACT:

Background

Rotator cuff tendinopathy (RCT) is a major contributor to over 30 million surgeries which are conducted to treat shoulder overuse injuries worldwide annually. Accumulating evidence indicates that neuropsychiatric disorders (ND) share pathogenic pathways with tendinopathy. However, unclarified causal relationships between these two disease spectra undermine the individualized design of treatment strategies benefiting patients with ND while minimizing the RCT risk. We aimed to unveil whether ND were genetically associated with increased RCT occurrence by conducting a two-sample Mendelian randomization (MR) algorithm.

Methods

Genome-wide association studies (GWAS) data of attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorde

SUBMITTER: Zhang W 

PROVIDER: S-EPMC12856381 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature