Digital Engagement Significantly Enhances Weight Loss Outcomes in Adults With Obesity Treated With Tirzepatide: Retrospective Cohort Study of a Digital Weight Loss Service.

ABSTRACT:

Background

The advent of tirzepatide has transformed obesity care; yet, real-world weight loss outcomes necessarily depend on patient engagement with behavioral support. Digital platforms offering coaching, self-monitoring, and automated feedback have the potential to further augment pharmacological efficacy.

Objective

The aim of the study is to examine associations between digital engagement and weight loss outcomes among adults prescribed tirzepatide in routine care over 12 months and to identify baseline correlates of engagement.

Methods

In this retrospective cohort study, we included adults (18-75 years; BMI ≥30 or ≥27.5 kg/m² with comorbidities) who initiated tirzepatide between February 2024 and August 2025 via a UK digital weight loss service. Engage

SUBMITTER: Johnson H 

PROVIDER: S-EPMC12856402 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature