An Integrated QSM-Radiomics Nomogram With Clinical and Imaging Markers for Stratifying Cognitive Impairment in Hypertension.

ABSTRACT:

Background

Hypertensive cognitive impairment is associated with increased iron deposition in deep gray matter. This study aimed to evaluate the potential clinical application of quantitative susceptibility mapping (QSM)-based radiomics for stratifying cognitive impairment in hypertensive patients.

Methods

We prospectively enrolled 178 hypertensive patients who underwent QSM examination and categorized them into cognitive impairment group and normal cognition group. The workflow included: (1) Precise 3D segmentation and susceptibility quantification of the basal ganglia; (2) Initial radiomics feature extraction from the target regions, followed by optimal feature selection via variance thresholding, maximum relevance minimum redundancy (mRMR) algorithm, and LASSO regression;

SUBMITTER: Su Y 

PROVIDER: S-EPMC12856517 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature