Neurostructural Substrates of Hierarchical Dimensions of Internalizing Symptoms in Youth.

ABSTRACT: Internalizing symptoms are common in childhood and linked to meaningful differences in brain structure, yet their organization and neurobiological correlates during this developmental period remain poorly understood. An increasing number of studies conceptualize internalizing psychopathology as dimensional, transdiagnostic, and hierarchical, yet the factor structure of these symptoms in youth remains to be clearly defined. Additionally, the neurostructural underpinnings of internalizing factors warrants further investigation in younger samples. Using a large sample (N = 11,868) of 9- to 10-year-old children from the Adolescent Brain Cognitive Development^SM (ABCD Study), we examined the factor structure of internalizing symptoms and identified associated neurostructural correlate

SUBMITTER: Durham EL 

PROVIDER: S-EPMC12856526 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature