Comparative multi-omics in female mice reveals tissue-specific vulnerabilities to chronic alcohol intake.

ABSTRACT:

Background

Alcohol-related liver disease (ALD) and alcohol-related myopathy are consequences of chronic alcohol use. However, understanding of the associated molecular mechanisms and effective treatments remains limited.

Methods

Multi-omics were employed to uncover molecular blueprints of liver versus skeletal muscle responses to chronic alcohol exposure, using a preclinical mouse model showing signs of alcohol-related liver dysregulation (diminished liver phosphatidylcholine-to-phosphatidylethanolamine lipid ratio) and alcohol-related myopathy (reduced muscle mass and strength).

Results

A greater proportion of transcriptomic, proteomic, and metabolomic features were altered by alcohol in liver than muscle, whereas similar proportions of lipid species were affected in

SUBMITTER: Willis CRG 

PROVIDER: S-EPMC12856532 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature