Ferroptosis and retinal ganglion cell death in glaucoma: Mechanisms and therapeutic approaches.

ABSTRACT: Glaucoma represents a predominant worldwide etiology of permanent vision impairment; it is clinically manifested through progressive neuronal atrophy in retinal ganglion cells (RGCs) and is accompanied by axonal degeneration in the optic pathway. Given the limited efficacy of conventional intraocular pressure-lowering therapies in halting RGC degeneration, the exploration of novel neuroprotective strategies has become imperative. An increasing amount of research emphasizes the pathogenic role of ferroptosis, a metal ion-associated programmed cellular demise mechanism recently implicated in neurodegenerative cascades, as a pivotal executor of RGC demise and putative central mechanism in glaucomatous pathology. This comprehensive review systematically examines the mechanistic interplay betwe

SUBMITTER: Qin M 

PROVIDER: S-EPMC12856606 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature