Spin Relaxation Does Not Preclude Magnetic Field Effects on Lipid Autoxidation.

ABSTRACT: Spin correlations between radicals underpin key biological processes, and spin relaxation describes their decay due to environmental interactions. Radical pairs involving lipid peroxide radicals in bilayers have been proposed as a source of magnetic field effects (MFEs) in lipid autoxidation, but their viability has been questioned due to rapid relaxation in dynamic membranes. This study investigates whether MFEs can persist in lipid bilayers despite spin relaxation. Using an integrative approach combining all-atom molecular dynamics simulations, density functional theory (DFT) calculations, and spin dynamics modeling using Bloch-Redfield-Wangsness relaxation theory, we investigate a palmitoyl-linoleoyl-phosphatidylcholine (PLPC) model membrane containing 13ze-lipid peroxide radicals. We i

SUBMITTER: Gruning G 

PROVIDER: S-EPMC12856652 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature