White Matter Hyperintensity Burden and Decline in Driving Performance Among Older Adults.

ABSTRACT:

Importance

White matter hyperintensity (WMH) burden is associated with cognitive decline, but its association with driving performance among older adults and the associations of modifiable risk factors remain unclear.

Objective

To evaluate the association of total and regional WMH burden with longitudinal naturalistic driving performance in cognitively normal older adults and evaluate moderating associations of cognitive decline and antihypertensive therapy.

Design, setting, and participants

This prospective longitudinal cohort study enrolled community-dwelling older adults (≥65 years) in the Driving Real-World In-Vehicle Evaluation System Project. Baseline 3-T brain magnetic resonance imaging (MRI) scans and data from continuous in-vehicle driving monitoring were col

SUBMITTER: Parihar M 

PROVIDER: S-EPMC12856682 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature