HPV vaccination following cervical intraepithelial neoplasia grade 2 diagnosis and risk of progression.

ABSTRACT:

Introduction

Human papillomavirus (HPV) vaccination is associated with a significantly reduced risk of cervical cancer when administered before initial exposure to HPV. Women with high-grade cervical intraepithelial neoplasia (CIN) have an increased risk of subsequent HPV-related disease, including recurrent high-grade CIN, compared to women without CIN. Some clinicians have advised women with high-grade CIN to undergo HPV vaccination to reduce their subsequent risk, despite a lack of evidence for this practice. We aimed to evaluate whether HPV vaccination of women undergoing active surveillance for CIN grade 2 (CIN2) is associated with a decreased risk of progression to cervical intraepithelial neoplasia grade 3 or worse (CIN3+).

Material and methods

We conducted a nationwi

SUBMITTER: Eriksen DO 

PROVIDER: S-EPMC12856700 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature