Prenatal diagnosis and perinatal outcomes of fetuses with congenital duodenal obstruction: A nine-year retrospective study from China.

ABSTRACT:

Introduction

Congenital duodenal obstruction (CDO) is one of the most common fetal gastrointestinal anomalies, but previous prenatal studies tend to investigate CDO as a portion of gastrointestinal obstruction. Few studies describe the genetic findings of CDO, especially copy number variants, in fetal cohorts with a relatively large sample size. The study aims to investigate the detection rate of genetic causes at different levels and to explore the potential influencing factors of perinatal outcomes of fetuses with CDO.

Material and methods

This retrospective study analyzed karyotype, chromosomal microarray analysis, and trio-whole exome sequencing (trio-WES) results of singleton fetuses suspected of CDO in a tertiary center between January 2014 and September 2023. In addit

SUBMITTER: Lu J 

PROVIDER: S-EPMC12856708 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature