The threshold of estradiol level for fresh embryo transfer differs between blastocyst and cleavage-stage embryo.

ABSTRACT:

Introduction

Ovarian stimulation can cause supraphysiological estradiol levels and adverse effects on endometrial receptivity. Since patients could undergo cleavage or blastocyst stage embryo transfer, the threshold value of peak estradiol level for each transfer stage that impacts the pregnancy outcomes of fresh versus frozen embryo transfer remains unclear. This work aims at answering the following questions: what is the threshold of peak estradiol level that modifies the difference in pregnancy outcomes between fresh and frozen embryo transfer and whether the threshold value varies with the stage of embryo transferred?

Material and methods

A secondary analysis of data from four multicenter randomized trials with similar design comparing the rate of live birth between fres

SUBMITTER: Zhao D 

PROVIDER: S-EPMC12856715 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature