Adhesion molecules in the maternal-fetal interface in healthy pregnancies and preeclampsia.

ABSTRACT:

Introduction

Adhesion molecules are markers of endothelial activation, and they are involved in placentation and inflammation. We compared levels of vascular cell adhesion molecule-1 (VCAM1), intercellular adhesion molecule-1 (ICAM1), and E-selectin (SELE) in maternal and fetal vessels of preeclampsia and healthy pregnancies. Furthermore, we investigated if the placenta releases adhesion molecules.

Material and methods

Blood was sampled from three maternal (antecubital vein, uterine vein, and radial artery as a proxy for the uterine artery) and two fetal vessels (umbilical vein and artery) in 75 healthy pregnancies and 37 cases of preeclampsia undergoing cesarean delivery. Samples were also collected among 70 healthy pregnancies and 35 preeclampsia cases at three visits (ges

SUBMITTER: Frisch IK 

PROVIDER: S-EPMC12856719 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature