Paternal age effect: Replication in schizophrenia with intriguing dissociation between bipolar with and without psychosis.

ABSTRACT: Advanced paternal age (APA) is a risk factor for schizophrenia (Sz) and bipolar disorder (BP). Putative mechanisms include heritable genetic factors, de novo mutations, and epigenetic mechanisms. Few studies have explored phenotypic features associated with APA. The Genomic Psychiatry Cohort established a clinically characterized repository of genomic samples from subjects with a Sz-BP diagnosis or unaffected controls, 12,975 with parental age information. We estimated relative risk ratios for Sz, schizoaffective depressed and bipolar types (SA-D, SA-B), and BP with and without history of psychotic features (PF) relative to the control group, comparing each paternal age group to the reference group 20-24 years. All tests were two-sided with adjustment for multiple comparisons. Subjects wit

SUBMITTER: Lehrer DS 

PROVIDER: S-EPMC12856734 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature