Biomimetic Nanotechnology Overcoming the Blood-Testis Barrier for Testicular Protection in Chemotherapy.

ABSTRACT: Cancer patients exposed to chemotherapeutic drugs and whole-body radiation can result in testicular injury and germ cell loss. One of the mechanisms is that these drugs lead to the accumulation of reactive oxygen species (ROS) in the testes, which has been documented to cause testicular damage. Therefore, this highlights the critical need for ROS clearance in testes to preserve male fertility during cancer treatment. The blood-testis barrier (BTB) poses a major challenge, due to the absence of effective pharmaceutical agents that can penetrate this barrier to neutralize ROS effectively. We synthesized nanomaterials based on manganese-superoxide dismutase (PCN-222-Mn), demonstrating the ability to cross BTB and facilitate ROS clearance. Real-time T1-weighted magnetic resonance imaging confi

SUBMITTER: An C 

PROVIDER: S-EPMC12856846 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature