Click-to-Release Reactions for Tertiary Amines and Pyridines.

ABSTRACT: Click-to-release reactions, transformations that liberate molecules of interest under physiological conditions, are gaining traction as powerful means to control biological processes and enable spatiotemporal drug delivery. A major limitation of current click-to-release strategies remains their narrow scope of releasable functional groups, leaving many classes of bioactive molecules incompatible with such approaches. This study provides the first examples of click-to-release reactions for tertiary amines and pyridines. Two orthogonal strategies were developed based on bioorthogonal reactions between isonitriles and tetrazines. Isocyanopropyl (ICPr) groups were used to cage tertiary amines and pyridines, enabling their release upon reaction with tetrazines under mild conditions. Similarly,

SUBMITTER: Chojnacki K 

PROVIDER: S-EPMC12856886 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature