Contact Electrification-Based Enantioselective Recognition of Chiral Amino Acids through Stereospecific Interfacial Electron Transfer.

ABSTRACT: Chirality lies at the heart of chemistry, governing the structure-function relationships of biomolecules, pharmaceuticals, and catalysts. However, rapid and label-free enantioselective analysis remains an enduring challenge due to the intrinsic similarity of enantiomers' physicochemical properties. Here, we report a contact electrification-based triboelectric sensing platform for the enantioselective recognition of chiral amino acids, achieved by coating CuO nanowires. The approach exploits chirality-dependent interfacial electron transfer, whereby differences in molecular orbital alignment and work function between enantiomers generate distinct electronic signatures during controlled contact-separation with acetone. Kelvin probe force microscopy, ultraviolet photoelectron spectroscopy, an

SUBMITTER: Pal A 

PROVIDER: S-EPMC12856897 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature