Near-Field Topology-Optimized Superchiral Metasurfaces for Enhanced Chiral Sensing.

ABSTRACT: The detection and discrimination of molecular chirality are essential for the advancement of pharmaceutical and biological applications. While nanophotonic platforms offer a route to enhance chiral light-matter interactions, existing device concepts for chiral sensing remain heuristic, resulting in limited chiral enhancement and control over chiral hotspot placement within nanostructures. Here, we introduce an inverse design framework that directly optimizes superchiral near fields in photonic nanostructures and demonstrate its powerful opportunities for enantioselective analysis. We first show that freeform achiral metasurfaces can be optimized to achieve an 820-fold chiral density enhancement with fully customizable chiral hotspot placement for direct molecular interaction. We then lever

SUBMITTER: Jiang Z 

PROVIDER: S-EPMC12856900 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature