Unified Synthesis Platform for 1,2,3-Trisubstituted Cyclopentadienyl Ligands Decouples Sterics from Electronics.

ABSTRACT: Cyclopentadienyl (Cp) ligands are a cornerstone of coordination chemistry and transition-metal catalysis. Their tuning profoundly influences the chemical and biological reactivity, the induced selectivity, and the stability of the corresponding metal complexes. However, compared to phosphines for instance, the accessible chemical space of Cps is rather narrow, exhibiting major limitations regarding the nature, pattern, and number of Cp substituents. A unified synthetic strategy toward partially substituted Cps bearing diverse functionalities and closing gaps in chemical space is highly desirable. Herein, we report a streamlined general strategy to prepare 1,2,3-trisubstituted cyclopentadienes (1,2,3-Cps) from a central inexpensive precursor. Operationally straightforward reactions and puri

SUBMITTER: Van Den Bossche B 

PROVIDER: S-EPMC12856903 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature